Characterization of myxovirus sialidase
Identifieur interne : 002B96 ( Main/Exploration ); précédent : 002B95; suivant : 002B97Characterization of myxovirus sialidase
Auteurs : T. Aoyagi [Japon] ; T. Komiyama [Japon] ; K. Nerome [Japon] ; T. Takeuchi [Japon] ; H. Umezawa [Japon]Source :
- Experientia [ 0014-4754 ] ; 1975-08-01.
English descriptors
- Teeft :
Abstract
Zusammenfassung: Die Sialidasen von Myxoviren zeigten eine ähnliche Substratspezifität wie die Streptomyces-Sialidase. Siastatin A und B, Produkte von Streptomycesarten, wurden auf ihre hemmende Wirkung gegen Sialidasen verschiedenster Herkunft untersucht und als spezifische Hemmstoffe gegen bakterielle Sialidasen erkannt. Siastatin A und B hemmen die Sialidase der Chorioallantoismembran, nicht aber die Sialidasen von Myxoviren. Daraus folgt, dass virale Sialidasen in infizierten Wirtszellen de novo zusammengesetzt werden.
Url:
DOI: 10.1007/BF02358837
Affiliations:
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